Vesicular transporters: old story, fresh look!

Barcelona, Spain
July 13th 2012

A satellite event of the 8th FENS forum

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The functioning of the mammalian nervous system depends on a delicate modulation of synapse functions. Exocytotic release of neurotransmitters and gliotransmitters requires their accumulation inside secretory organelles. For each transmitter, specific vesicular transporters allow loading and storage of the neuroinformative molecules in the secretory organelles. The recent progress on the biophysic, pharmacology and function of vesicular transporters is advancing the frontiers about mammalian neurotransmission with implications for the pathophysiology of human diseases, forcing us to have a fresh look on this old story.

Presentations will focus on the most recent discoveries on the neurobiology of these vesicular transporters that are central elements for synapse functions and cognition in relation with brain diseases such as Alzheimer disease, epilepsy, pain and deafness. Finally, vesicular release of neuromodulators is not the hallmark of the sole excitable nerve cells as compelling evidence show that astroglia, the forgotten partner of neurons at synapses are also competent for storing and releasing through exocytosis different neuromodulators.